Castleman disease: delineating the spectrum
نویسندگان
چکیده
منابع مشابه
Delineating the GRIN1 phenotypic spectrum
OBJECTIVE To determine the phenotypic spectrum caused by mutations in GRIN1 encoding the NMDA receptor subunit GluN1 and to investigate their underlying functional pathophysiology. METHODS We collected molecular and clinical data from several diagnostic and research cohorts. Functional consequences of GRIN1 mutations were investigated in Xenopus laevis oocytes. RESULTS We identified heteroz...
متن کاملCastleman disease
Castleman and Towne described a disease presenting as a mediastinal mass resembling thymoma. It is also known as "giant lymph node hyperplasia", "lymph node hamartoma", "angiofollicular mediastinal lymph node hyperplasia", and "angiomatous lymphoid hyperplasia". The pathogenesis is unknown, but the bulk of evidence points toward faulty immune regulation, resulting in excessive B-lymphocyte and ...
متن کاملThe plasmablasts in Castleman disease.
To the Editor In their article, Hsi et al 1 described the broad spectrum of histopathologic features of Castleman disease (CD). We would like to report one additional peculiar case, rich in human herpesvirus-8 (HHV-8)–infected plasmablasts (PBs), which we recently observed in our institution. The normal PB is a short-lived, very mobile B cell that can secrete antibodies but retains characterist...
متن کاملIntrathoracic Castleman disease.
AIM To analyze patients with Castleman disease who were diagnosed by surgery. MATERIALS AND METHODS We retrospectively investigated the postoperative pathological records of operations performed between January 1992 and December 2012 in our hospital. Files of 19 patients with the diagnosis of Castleman disease were analyzed. RESULTS There were 13 male and 6 female patients with a mean age o...
متن کاملPeripancreatic Castleman disease.
CONTEXT Castleman disease or giant lymph node hyperplasia is a rare disorder of the lymphoid tissue, usually occurring in the mediastinum. We report a case of localized peripancreatic plasma cell type Castleman disease, which is an unusual site. CASE REPORT A 45-year-old woman with a history of mild epigastric pain radiating to the back for the previous year was admitted and her physical exam...
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ژورنال
عنوان ژورنال: British Journal of Haematology
سال: 2017
ISSN: 0007-1048
DOI: 10.1111/bjh.15016